Which statement about NSAIDs in myositis is described as stomach-friendly?

Which statement about NSAIDs in myositis is described as stomach-friendly?

• A. They are not effective
• B. They cause stomach ulcers
• C. They are the only treatment
• D. Mobi and Celebrex are good anti-inflammatory agents that aren't bad on your stomach

Answer: (D)

The idea here is GI tolerability of NSAIDs based on how they block COX enzymes. Nonselective NSAIDs block both COX-1 and COX-2; COX-1 helps protect the stomach lining, so inhibiting it can lead to stomach irritation and ulcers. Drugs with COX-2 preference or selectivity, like meloxicam (Mobic) and celecoxib (Celebrex), reduce inflammation while sparing much of the stomach’s protective prostaglandins. In myositis, using these agents can provide pain and inflammation relief with a relatively better stomach tolerability profile, which is why they’re described as stomach-friendly. The other statements don’t capture this nuance: NSAIDs can be effective but aren’t the only treatment; they aren’t inherently stomach-friendly in general if nonselective, and they don’t universally lack GI risk.

The idea here is GI tolerability of NSAIDs based on how they block COX enzymes. Nonselective NSAIDs block both COX-1 and COX-2; COX-1 helps protect the stomach lining, so inhibiting it can lead to stomach irritation and ulcers. Drugs with COX-2 preference or selectivity, like meloxicam (Mobic) and celecoxib (Celebrex), reduce inflammation while sparing much of the stomach’s protective prostaglandins. In myositis, using these agents can provide pain and inflammation relief with a relatively better stomach tolerability profile, which is why they’re described as stomach-friendly. The other statements don’t capture this nuance: NSAIDs can be effective but aren’t the only treatment; they aren’t inherently stomach-friendly in general if nonselective, and they don’t universally lack GI risk.